​​​​Personalizing Psychosocial Intervention for Children with Disruptive Behaviour

Investigators: Brendan F. Andrade, Ph.D., Joe Beitchman, M.D., Joanna Henderson, Ph.D., E.B. Brownlie, Ph.D., Gloria Chaim, MSW., Tracey Skilling, Ph.D., Debbie Schachter, M.D

Introduction: This study will develop and test the predictive value of personalized clinical profiles of children with Disruptive Behavior Disorder based on important psychological and neuropsychological indicators. Importantly, the study aims to answer the clinical question, "Which psychosocial treatments work for whom?"                                                                                                             

Objectives: The primary objectives are : 1)To determine clinical profiles of children aged 6 - 9 and 10 - 12 with Disruptive Behaviour based on DSM-5 symptom dimensions and key domains of other psychopathology and neuropsychological functioning; 2) To determine whether these profiles improve our ability to predict which subgroups of children with Disruptive Behaviour are most likely, and least likely, to benefit from evidence-based cognitive-behavioural treatment; and 3) To use the study findings to develop an evidence-informed clinician decision aid, or other tools and intervention strategies, to positively impact the assessment and treatment of children with Disruptive Behaviour.   

Health and Clinical Relevance:  Findings from this study will lead to a better understanding of which children benefit from which treatments and to innovative opportunities for personalized care pathways for children with complex disruptive behaviour.    

Project Stage: Recruitment and Treatment Implementation

Funding Source: Canadian Institutes of Health Research (CIHR)


Canadian Institutes of Health Research (CIHR)

Addressing Depression and Positive Parenting Techniques

Investigators:  Brendan F. Andrade, Ph.D., Aliza Israel, MD, FRCPC

Introduction: The aim of the research is to determine the feasibility of novel assessment and treatment for parents with depression that builds parent's functional cognitions, emotion regulation, parenting competencies and skills.

Objectives: The primary objectives are: 1) To conduct a needs assessment survey to evaluate the feasibility of recruitment for this type of treatment in the given population; 2) To determine objective emotional, cognitive and behavioural markers that may improve the precision of clinical assessment; and 3) To evaluate the feasibility and acceptability of a novel targeted treatment for depressed parents of children with EBD, along with adherence to study protocol. We will use the results of the pilot study to make key modifications to study procedures and the treatment itself to increase the success of a future randomized controlled trial (RCT) to test treatment efficacy.

Health and Clinical Relevance: Important parental factors associated with depression, such as parental cognitions, and parental emotional and behavioural regulation skills, have largely been ignored when designing novel interventions. Systematically understanding differences between parents with and without depression on these key factors and the feasibility of novel treatment will identify avenues for treatment innovation.

Project Stage: Not Yet Recruiting

Funding Source: CAMH Discovery Fund


Completed Studies: 

The Clinic-Adapted Coping Power Program and Individualized Child and Family Treatment: A Randomized and Controlled Effectiveness Trial

Investigators: Brendan F. Andrade, Ph.D., Dt Browne, Ph.D., M, Wade, Ph.D., R Tannoc​​k, Ph.D. ​​

Introduction: This Randomized Controlled Trial (RCT) compared the benefits of 15-sessions of a clinic-modified version of the multi-component Coping Power program to tailored Individualized child and parent treatment. Children with elevated levels of disruptive behaviour and/or diagnoses of Oppositional Defiant Disorder or Conduct Disorder aged 9 - 12 years were recruited from an urban mental health hospital in Canada and randomized to conditions. Pre- post- and 6-month follow-up assessments were completed. 

Objectives: To determine the relative effectiveness of Coping Power compared to Individualized treatment for reducing conduct problems and externalizing behavior in a hospital mental health clinic.

Project Results: Results indicate that following intervention, both conditions showed similar and significant reductions in parent reported Conduct Problems and Externalizing Behaviour, with moderate effects. In addition, high levels of client satisfaction and clinician fidelity to treatment were reported. Manuscript in Preparation

Health and Clinical Relevance:  Findings demonstrate the effectiveness of Coping Power and Individualized treatment as evidence-based models of care for use with clinically complex children in a hospital setting.

Funding Source: Ontario Mental Health Foundation (OMHF); Canadian Child Health Clinician Scientist Program (CCHCSP), University of Toronto Faculty of Medicine Dean's Fund


                Ontario Mental Health Foundation (OMHF)                  Canadian Child Health Clinician Scientist Program (CCHCSP)


                                                   University of Toronto Faculty of Medicine Dean's Fund